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all content copyright Cell Therapy 2008. designed by:
all content copyright Cell Therapy 2008. designed by:
The objective of the Cell Therapy Translational Research Laboratory is to develop pre-clinical models that will provide the basis for novel clinical trials, as well as carry out basic research to further our understanding of cell characteristics and behaviour.
There are two main research themes in the lab: immunotherapy and mesenchymal stromal cells (MSC).
Our focus is on cells of the innate immune system, such as natural killer (NK) cells, NK cell lines and gamma delta T cells, and their application in the treatment of a variety of cancers, including leukemia and lymphoma. We are also investigating the use of antigen-specific cytotoxic T-cells for multiple indications. The work spans in vitro and pre-clinical animal models and extends to the development of early phase clinical trials.
In the area of mesenchymal stromal cells (MSC), our investigations have
focused on the role of MSC in the regeneration of a variety of tissues,
including cardiac, spinal cord, brain, vasculature and in wound healing. In
addition, we are also interested in the immune modulatory function of MSC in
bone marrow transplantation to reduce graft versus host disease, as well as
for suppression of autoimmune diseases.
Many of these studies are done in collaboration with leading investigators in each field. Studies include pre-clinical small animal models and in vitro work.
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